The Purpose of this study was to compare and evaluate alcoholic and aqueous extracts of bark, seeds, leaves and roots of Acacia nilotica Linn (AN) through oral glucose tolerance and hypoglycemic activities. Oral glucose tolerance test (OGTT) was investigated in glucose loaded rats and hypoglycemic activity was assessed in fasted normal rats at same dose level of 200 mg kg-1 respectively. The activities were compared with standard drug Glibenclamide (0.1 mg kg-1). The alcoholic bark extract showed marked reduction in blood glucose level of 42.41% in glucose loaded rats and 37.82% in fasted normal rats. Administration of alcoholic bark extract to glucose loaded/normal fasted rats caused significant (P<0.001) decrease in glucose level next to it is bark aqueous extract followed by alcoholic and aqueous extract of seed, leaves and roots. The study explains the basis for use of plant extract as food adjuvant to lower blood glucose level.
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